Pharmacologic Substance
cimetidine Audio
ci·met·i·dine [ suh-met-i-deen ]
Brand Names:
Tagamet
Effect:
Decreased Histamine Activity; Inhibition Gastric Acid Secretion
May Prevent:
Duodenal Ulcer; Gastrointestinal Hemorrhage; Stomach Ulcer
May Treat:
Duodenal Ulcer; Dyspepsia; Esophagitis, Peptic; Gastroesophageal Reflux; Heartburn; Helicobacter Infections; Stomach Ulcer; Urticaria; Zollinger-Ellison Syndrome
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to cimetidine:
  • A drug usually used to treat stomach ulcers and heartburn. It is also commonly used in a regimen to prevent allergic reactions.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A histamine H(2)-receptor antagonist. Enhancing anti-tumor cell-mediated responses, cimetidine blocks histamine's ability to stimulate suppressor T lymphocyte activity and to inhibit natural killer (NK) cell activity and interleukin-2 production. Cimetidine also may inhibit tumor growth by suppressing histamine's growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Histamine congener; competitively inhibits histamine binding to H2 receptors, inhibits gastric acid secretion, pepsin, and gastrin output, and blocks the activity of cytochrome P-450.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.