Pharmacologic Substance
clofarabine
[ kloh-fayr-uh-been ]
Brand Names:
Clolar
Effect:
Decreased Cell Membrane Integrity; Decreased DNA Integrity; Decreased DNA Replication; Increased Cellular Death
May Treat:
Leukemia, Lymphoid
More Information:
Definitions related to clofarabine:
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A drug used to treat certain types of acute lymphoblastic leukemia in children. It is also being studied in the treatment of other types of cancer. Clolar is a type of nucleoside analog.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factors, which activate apoptosis.NCI ThesaurusU.S. National Cancer Institute, 2021
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An adenine arabinonucleoside derivative that acts as an antineoplastic antimetabolite. It is used in the treatment of ACUTE LYMPHOID LEUKEMIA in pediatric patients who have relapsed.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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