Pharmacologic Substance
clofarabine Audio
[ kloh-fayr-uh-been ]
Brand Names:
Clolar
Effect:
Decreased Cell Membrane Integrity; Decreased DNA Integrity; Decreased DNA Replication; Increased Cellular Death
May Treat:
Leukemia, Lymphoid
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to clofarabine:
  • A drug used to treat certain types of acute lymphoblastic leukemia in children. It is also being studied in the treatment of other types of cancer. Clolar is a type of nucleoside analog.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factors, which activate apoptosis.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An adenine arabinonucleoside derivative that acts as an antineoplastic antimetabolite. It is used in the treatment of ACUTE LYMPHOID LEUKEMIA in pediatric patients who have relapsed.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.