Pharmacologic Substance
clomiphene Audio
clom·i·phene [ klom-uh-feen, kloh-muh- ]
Brand Names:
Serophene
Effect:
Increased GnRH Secretion; Stimulate Ovarian Follicular Phase; Stimulate Ovulation
May Treat:
Infertility, Female; Infertility, Male
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to clomiphene:
  • A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that ENCLOMIPHENE and ZUCLOMIPHENE are the (E) and (Z) isomers of Clomiphene respectively.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A triphenylethylene nonsteroidal ovulatory stimulant evaluated for antineoplastic activity against breast cancer. Clomiphene has both estrogenic and anti-estrogenic activities that compete with estrogen for binding at estrogen receptor sites in target tissues. This agent causes the release of the pituitary gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to ovulation. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • USP lists as a gonad stimulating principle; is a fertility inhibitor in male and female rats, but is a fertility stimulant in women used to induce multiple births.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.