Cell
cytotoxic T lymphocyte
[ sy-toh-tok-sik ... lim-foh-site ]
Subclass of:
Cytokine-Induced Killer Cells;
CD8-Positive T-Lymphocytes;
T-Lymphocyte Subsets
Definitions related to cytotoxic t-lymphocytes:
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(cytotoxic t lymphocyte) A type of immune cell that can kill certain cells, including foreign cells, cancer cells, and cells infected with a virus. Cytotoxic T lymphocytes can be separated from other blood cells, grown in the laboratory, and then given to a patient to kill cancer cells. A cytotoxic T lymphocyte is a type of white blood cell and a type of lymphocyte.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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(cytotoxic t lymphocyte) Antibody-independent "killer cells" derived from the CD8 T lymphocyte line which, when stimulated by antigen, MHC class I antigen, and interleukin 2, secrete cytolytic pore-forming proteins capable of lysing target cells.CRISP ThesaurusNational Institutes of Health, 2006
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(t-lymphocytes, cytotoxic) Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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