Pharmacologic Substance
dantrolene
[ dan-truh-leen ]
Brand Names:
Dantrium; Revonto; Ryanodex
Effect:
Decreased Striated Muscle Contraction; Decreased Striated Muscle Tone; Striated Muscle Metabolic Alteration
May Treat:
Cerebral Infarction;
Cerebral Palsy;
Malignant Hyperthermia;
Multiple Sclerosis;
Muscle Spasticity;
Neuroleptic Malignant Syndrome;
Spinal Cord Injuries
More Information:
Definitions related to dantrolene:
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A hydantoin derivative and direct-acting skeletal muscle relaxant. Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1, and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from the sarcoplasmic reticulum, an essential step in muscle contraction.NCI ThesaurusU.S. National Cancer Institute, 2021
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Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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