Pharmacologic Substance
mephenytoin
Effect:
Decreased Disorganized Electrical Activity; Decreased Organized Electrical Activity
May Treat:
Epilepsy, Post-Traumatic; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic
Definitions related to mephenytoin:
  • A heterocyclic organic compound with anticonvulsant property. Although the mechanism of action is not well established, mephenytoin potentially promotes sodium efflux from neurons in motor cortex, and stabilizes the threshold against hyperexcitability caused by excessive stimulation. Thus this agent reduces the membrane sodium gradient and prevents cortical seizure signal spreading. It may cause blood dyscrasias, therefore, this agent was only used after other less toxic anticonvulsants had failed.
    NCI
    U.S. National Cancer Institute, 2021
  • An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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