Pharmacologic Substance
darbepoetin alfa Audio
[ dar-bee-poh-ee-tin al-fuh ]
Brand Names:
Aranesp
Effect:
Increased Erythroid Cell Production; Increased Erythropoetin Secretion
May Treat:
Anemia
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to darbepoetin alfa:
  • A recombinant analog of the endogenous cytokine erythropoietin, an erythropoiesis-stimulating protein. Due to the addition of two carbohydrate chains, darbepoetin alfa exhibits a three-fold greater half-life than does erythropoietin. Similar to erythropoietin, darbopoietin alfa binds to and activates epoetin receptors, thereby inducing the differentiation and maturation of erythrocyte progenitors, stimulating endothelial cell proliferation, and stimulating B-cell proliferation and immunoglobulin production. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • A recombinant protein which stimulates ERYTHROPOIESIS used to treat ANEMIA.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A substance made in the laboratory that stimulates the bone marrow to produce red blood cells. It belongs to the family of drugs called antianemics.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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