Pharmacologic Substance
darunavir
Brand Names:
Prezcobix; Prezista; Symtuza
Effect:
Decreased Protein Synthesis
May Treat:
Acquired Immunodeficiency Syndrome
More Information:
Definitions related to darunavir:
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A human immunodeficiency virus type 1 (HIV-1) protease nonpeptidic inhibitor, with activity against HIV. Upon oral administration, darunavir selectively targets and binds to the active site of HIV-1 protease, and inhibits the dimerization and catalytic activity of HIV-1 protease. This inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions, and prevents HIV replication.NCI ThesaurusU.S. National Cancer Institute, 2021
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An HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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