Pharmacologic Substance
desipramine
[ duh-zip-ruh-meen, dez-uh-pram-in ]
Brand Names:
Norpramin
Effect:
Decreased Serotonin Degradation; Increased Central Nervous System Norepinephrine Activity
May Treat:
Attention Deficit Disorder with Hyperactivity; Depressive Disorder; Pain; Substance-Related Disorders
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to desipramine:
  • A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An active metabolite of imipramine, a tertiary amine and a synthetic tricyclic derivative of the antidepressant. Desipramine enhances monoamine neurotransmission in certain areas of the brain by inhibiting the re-uptake of noradrenaline and serotonin at the noradrenergic and serotoninergic nerve endings, respectively. It also induces sedation through histamine 1 receptor blockage and hypotension through beta-adrenergic blockage.
    NCI
    U.S. National Cancer Institute, 2021
  • Tricyclic dibenzazepine compound that potentiates neurotransmission; desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport; this compound also possesses minor anticholingeric activity, through its affinity to muscarinic receptors.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.