Pharmacologic Substance
dexlansoprazole
Brand Names:
Dexilant
Effect:
Inhibition Gastric Acid Secretion
May Treat:
Esophagitis, Peptic; Gastroesophageal Reflux; Heartburn
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to dexlansoprazole:
  • The R-isomer of lansoprazole and a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. As a weak base, dexlansoprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.
    NCI
    U.S. National Cancer Institute, 2021
  • The R-isomer of lansoprazole that is used to treat severe GASTROESOPHAGEAL REFLUX DISEASE.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.