Pharmacologic Substance
dextromethorphan
Brand Names:
Babee Cof; Bromfed DM; Buckley's Cough Suppressant; Buckleys Mixture; Cepacol Sore Throat Plus Cough; Cepastat Sore Throat & Cough; Chloraseptic Sore Throat + Cough; Creomulsion; DayQuil Cough; Delsym; Elixsure Cough; Mielim Y Mas; Nuedexta; Robafen Cough; Scot-tussin Diabetic CF; Scot-Tussin DM Cough Chasers; Vanatab DM; Zicam Cough
Effect:
Decreased Medullary Respiratory Drive
May Prevent:
Cough
May Treat:
Cough
More Information:
Definitions related to dextromethorphan:
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A synthetic, methylated dextrorotary analogue of levorphanol, a substance related to codeine and a non-opioid derivate of morphine. Dextromethorphan exhibits antitussive activity and is devoid of analgesic or addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the central nervous system, thereby suppressing the cough reflex.NCI ThesaurusU.S. National Cancer Institute, 2021
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D-isomer of the codeine analog of levorphanol; dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center; this compound is an NMDA receptor antagonist (n-methyl-d-aspartate receptors) and acts as a noncompetitive channel blocker; it is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.CRISP ThesaurusNational Institutes of Health, 2006
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Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Dextromethorphan, synthetic drug related to morphine and used in medicine as a cough suppressant. The hydrobromide salt of dextromethorphan occurs as white crystals or a white crystalline powder, soluble in water, alcohol, and chloroform. It acts upon the central nervous system to suppress the...Encyclopedia Britannica, Inc., 2020
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