Organic Chemical
naloxone
nal·ox·one [ nuh-lok-sohn, nal-uh k-sohn ]
Brand Names:
Bunavail; Evzio; Kloxxado; Narcan; Suboxone; Zubsolv
Effect:
Central Nervous System Stimulation; Increased Blood Pressure; Increased Medullary Respiratory Drive
May Treat:
Opioid-Related Disorders;
Respiration Disorders;
Shock, Septic
More Information:
Definitions related to naloxone:
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A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A substance that is being studied as a treatment for constipation caused by narcotic medications. It belongs to the family of drugs called narcotic antagonists.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A thebaine derivate with competitive opioid antagonistic properties. Naloxone reverses the effects of opioid analgesics by binding to the opioid receptors in the CNS, and inhibiting the typical actions of opioid analgesics, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. Naloxone binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors in the CNS.NCI ThesaurusU.S. National Cancer Institute, 2021
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Specific opiate antagonist with no agonist activity, a competitive antagonist at mu, delta, and kappa opioid receptors.CRISP ThesaurusNational Institutes of Health, 2006
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