Pharmacologic Substance
diclofenac Audio
[ dy-kloh-feh-nak ]
Brand Names:
Aleve Arthritis Pain; Arthrotec; Cambia; Cataflam; Dyloject; Flector; Licart; Pennsaid; Solaraze; Surpass Anti-Inflammatory; Voltaren; Zipsor; Zorvolex
Effect:
Decreased Prostaglandin Production
May Treat:
Arthritis, Juvenile; Arthritis, Rheumatoid; Dysmenorrhea; Inflammation; Keratosis; Osteoarthritis; Photophobia; Spondylitis, Ankylosing
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to diclofenac:
  • A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • The active ingredient in a drug that is used to treat the symptoms of rheumatoid arthritis and is being studied in the prevention and treatment of some types of skin cancer. It blocks substances that cause inflammation and pain. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of cyclooxygenase inhibitor, a type of nonsteroidal anti-inflammatory drug (NSAID), and a type of antiangiogenesis agent.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.