Pharmacologic Substance
digitoxin Audio
dig·i·tox·in [ dij-i-tok-sin ]
Effect:
Conduction System Depolarization; Negative Chronotropy; Nodal Depolarization; Positive Inotropy
May Prevent:
Heart Failure
May Treat:
Anxiety Disorders; Atrial Fibrillation; Atrial Flutter; Cardiac Output, Low; Heart Failure; Shock, Cardiogenic; Tachycardia, Supraventricular
Definitions related to digitoxin:
  • A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI)
    NCI
    U.S. National Cancer Institute, 2021
  • A substance that is being studied as a treatment for cancer.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.