Pharmacologic Substance
diltiazem
[ dil-tahy-uh-zem ]
Brand Names:
Cardizem; Cartia; Dilt; Diltzac; Matzim; Taztia; Tiadylt; Tiazac
Effect:
Coronary Arterial Vasodilation; Decreased Blood Pressure; Negative Chronotropy
May Treat:
Angina Pectoris, Variant; Atrial Fibrillation; Atrial Flutter; Hypertension; Myocardial Infarction; Tachycardia, Supraventricular
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to diltiazem:
  • A benzothiazepine derivative with anti-hypertensive, antiarrhythmic properties. Diltiazem blocks voltage-sensitive calcium channels in the blood vessels, by inhibiting the ion-control gating mechanisms, thereby preventing calcium levels increase by other revenues. Alternatively, it has been suggested that this agent also interferes with the release of calcium from the sarcoplasmic reticulum and inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The overall low calcium levels leads to dilatation of the main coronary and systemic arteries and decreasing myocardial contractility, decreased peripheral arterial resistance, improved oxygen delivery to the myocardial tissue, and decreased cardiac output.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Substituted benzothiazepine with specific blocking activity against inward rectifying calcium channel.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.