Pharmacologic Substance
fenoldopam
Brand Names:
Corlopam
Effect:
Decreased Blood Pressure; Increased Collecting Duct Water Permeability; Increased Renal Na+ Excretion; Renal Arterial Vasodilation
May Treat:
Heart Failure; Hypertension, Malignant; Hypertension, Renovascular
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to fenoldopam:
  • 6-chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl) -3-benzazepine-7,8- diol; dopamine D1 agonist with diuretic and antihypertensive properties, used to treat congestive heart failure, chronic renal failure, and essential hypertension.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • A benzazepine derivative with vasodilatory and antihypertensive properties. Fenoldopam, a dopamine (DA) receptor agonist, binds specifically to peripheral DA1 receptors and to alpha-2 adrenoceptors with moderate affinity. However, this agent exhibits no significant affinity to DA2, other alpha adrenergic, beta adrenergic, muscarinic, or serotonergic receptors. Receptor binding modulates the transmembrane flux of ions, thereby stimulating adenylate cyclase activity, as well as the release of prolactin. This results in vasodilatation, increased renal blood flow thereby enhancing natriuresis and diuresis leading to a lowering in diastolic blood pressure.
    NCI
    U.S. National Cancer Institute, 2021
  • A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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