Antibiotic
distamycins
Subclass of:
Peptides
Definitions related to distamycins:
  • Oligopeptide antibiotics from Streptomyces distallicus. Their binding to DNA inhibits synthesis of nucleic acids.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • (distamycin antineoplastic antibiotic) An antineoplastic antibiotic isolated from the bacterium Streptomyces distallicus. Distamycin antibiotics bind to the minor groove of DNA, preferentially to adenine-thymine (A-T) rich sequences, thereby inhibiting DNA replication and RNA transcription. In addition to their antitumor effects, these agents possess antiviral and antiprotozoal activities.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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