Pharmacologic Substance
dopamine antagonist
do·pa·mine an·tag·o·nist [ doh-puh-meen an-tag-uh-nist ]
Subclass of:
Dopaminergic Agents
Definitions related to dopamine antagonists:
  • Any agent that binds to and blocks dopamine receptors.
    NCI
    U.S. National Cancer Institute, 2021
  • Class of drugs and natural products which inhibit dopaminergic function by decreasing dopamine biosynthesis, increasing dopamine degradation or reuptake, or interacting negatively with dopamine receptors.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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