Pharmacologic Substance
doxepin
[ dok-suh-pin ]
Brand Names:
Prudoxin; Silenor; Zonalon
Effect:
Decreased Serotonin Degradation; Increased Central Nervous System Norepinephrine Activity
May Treat:
Anxiety Disorders;
Depressive Disorder;
Dermatitis, Atopic;
Pain;
Pruritus
More Information:
Definitions related to doxepin:
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A dibenzoxepin derivative and tricyclic antidepressant (TCA) with antipruritic, antidepressive and anxiolytic activities. Doxepin blocks the reuptake of norepinephrine and serotonin (5-HT) into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their neurotransmission. Doxepin also has antagonistic effects on histamine H1, 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is mediated through inhibition of histamine receptors.NCI ThesaurusU.S. National Cancer Institute, 2021
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A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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