Vitamin
doxercalciferol
[ dok-ser-kal-sih-feh-rol ]
Brand Names:
Hectorol
Effect:
Bone Resorption Inhibition; Decreased PTH Secretion; Decreased Renal Ca++ Excretion; Stimulation Small Intestine Fluid/Electrolyte Absorption
May Treat:
Hyperparathyroidism
More Information:
Definitions related to doxercalciferol:
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A substance being studied in the prevention of recurrent prostate cancer. It is a type of vitamin D analog.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A synthetic analog of vitamin D with potential antineoplastic activity. In the liver, doxercalciferol is converted to its biologically active vitamin D metabolites, which control the intestinal absorption of dietary calcium, the tubular reabsorption of calcium by the kidney and, in conjunction with parathyroid hormone (PTH), the mobilization of calcium from the skeleton. Through interaction with specific receptor proteins in target tissues, these vitamin D metabolites act directly on osteoblasts to stimulate skeletal growth, and on the parathyroid glands to suppress PTH synthesis and secretion. This agent has also been shown to inhibit the growth of retinoblastomas, and may exhibit some antiproliferative activity against prostate cancer cells.NCI ThesaurusU.S. National Cancer Institute, 2021
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