Antibiotic
doxorubicin Audio
dox·o·ru·bi·cin [ dok-suh-roo-buh-sin ]
Brand Names:
Adriamycin; Doxil; LipoDox
Effect:
Decreased DNA Integrity; Decreased RNA Integrity
May Treat:
Breast Neoplasms; Gastrointestinal Neoplasms; Hodgkin Disease; Leukemia, Myeloid, Acute; Lung Neoplasms; Neuroblastoma; Osteosarcoma; Ovarian Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Soft Tissue Neoplasms; Thyroid Neoplasms; Urinary Bladder Neoplasms; Wilms Tumor
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to doxorubicin:
  • A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Doxorubicin comes from the bacterium Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline antitumor antibiotic.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.