Molecular Function
drug metabolism
drug me·tab·o·lism [ druhg muh-tab-uh-liz-uhm ]
Definitions related to drug metabolism:
-
A series of chemical modifications of a drug compound by enzymatic activity that make the substrate (drug) more water soluble to allow its clearance from the body. Drug metabolism occurs in two phases: Phase I (biotransformation) involves oxidation, hydroxylation reduction, and hydrolysis. Phase II (conjugation) involves synthesis and conjugation.NCI ThesaurusU.S. National Cancer Institute, 2021
-
The buildup and breakdown of drugs for utilization by the organism.CRISP ThesaurusNational Institutes of Health, 2006
-
(drug metabolic process) The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances are considered to be drugs, even if not used in medical or veterinary practice.Gene Ontology DictionaryGene Ontology Consortium, 2021
-
The liver is the principal site of drug metabolism (for review, see [1 ]). Although metabolism typically inactivates drugs, some drug metabolites are pharmacologically active--sometimes even more so than the parent compound. An inactive or weakly active substance that has an active metabolite is called a prodrug, especially if designed...Merck & Co., Inc., 2020
-
The liver is the principal site of drug metabolism. Although metabolism typically inactivates drugs, some drug metabolites are pharmacologically active--sometimes even more so than the parent compound. An inactive or weakly active substance that has an active metabolite is called a prodrug, especially if designed to deliver the active...Merck & Co., Inc., 2020
Return to OpenMD Medical Dictionary
> D
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.