Immunologic Factor
eculizumab Audio
[ ek-yoo-lih-zoo-mab ]
Brand Names:
Soliris
May Treat:
Atypical Hemolytic Uremic Syndrome; Hemoglobinuria, Paroxysmal
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to eculizumab:
  • A humanized monoclonal antibody directed against terminal complement protein C5. Eculizumab binds to terminal complement protein C5, thereby blocking C5 cleavage into pro-inflammatory components and blocking the complement-mediated destruction of paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. (NCI05)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A monoclonal antibody used to prevent red blood cells from being destroyed in patients with paroxysmal nocturnal hemoglobinuria (PNH), a red blood cell disorder. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body. Eculizumab blocks a protein in the blood that causes the breakdown of red blood cells.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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