Pharmacologic Substance
enalapril Audio
[ eh-na-luh-pril ]
Brand Names:
Epaned; Vaseretic; Vasotec
Effect:
Decreased Blood Pressure; Decreased Bradykinin Degradation; Decreased Intravascular Volume; Decreased Mineralocorticoid Secretion; Decreased Renal K+ Excretion; Increased Renal Na+ Excretion; Renal Arterial Vasodilation
May Prevent:
Diabetic Nephropathies; Hypertrophy, Left Ventricular; Ventricular Dysfunction, Left
May Treat:
Arthritis, Rheumatoid; Bartter Syndrome; Diabetic Nephropathies; Edema; Heart Failure; Hypertension, Malignant; Ventricular Dysfunction, Left
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to enalapril:
  • 1-carboxy-3-phenylpropyl-L-alanyl- L-proline (as 1'-ethyl ester, maleate 1:1), is an ACE inhibitor used as an antihypertensive.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • A dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
    NCI
    U.S. National Cancer Institute, 2021
  • An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An antihypertensive agent that can also be used to slow or prevent the progression of heart disease in people with childhood cancer treated with drugs that may be harmful to the heart.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.