Pharmacologic Substance
lisinopril Audio
[ ly-sih-noh-pril ]
Brand Names:
Prinivil; Prinzide; Qbrelis; Zestoretic; Zestril
Effect:
Decreased Blood Pressure; Decreased Bradykinin Degradation; Decreased Intravascular Volume; Decreased Mineralocorticoid Secretion; Decreased Renal K+ Excretion; Increased Renal Na+ Excretion; Renal Arterial Vasodilation
May Prevent:
Diabetic Nephropathies; Hypertrophy, Left Ventricular; Ventricular Dysfunction, Left
May Treat:
Diabetic Nephropathies; Heart Failure; Hypertension; Myocardial Infarction; Ventricular Dysfunction, Left
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to lisinopril:
  • A drug used to treat high blood pressure and certain heart conditions. It is also being studied in the prevention and treatment of side effects caused by some anticancer drugs. It blocks certain enzymes that cause blood vessels to constrict (narrow). It is a type of angiotensin-converting enzyme (ACE) inhibitor.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Lisinopril, a synthetic peptide derivative, specifically and competitively inhibits ACE, which results in a decrease in the production of the potent vasoconstrictor angiotensin II and, so, diminished vasopressor activity. In addition, angiotensin II-stimulated aldosterone secretion by the adrenal cortex is decreased which results in a decrease in sodium and water retention and an increase in serum potassium.
    NCI
    U.S. National Cancer Institute, 2021
  • Lysine derivative of the active form of enalapril; an angiotensin converting enzyme inhibitor used in the treatment of hypertension.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.