Immunologic Factor
enfuvirtide
Brand Names:
Fuzeon
Effect:
Decreased Endocytosis; Increased Immunologically Active Molecule Activity
May Treat:
Acquired Immunodeficiency Syndrome
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to enfuvirtide:
  • A short polypeptide with activity against human immunodeficiency virus (HIV). Enfuvirtide binds to the first heptad-repeat (HR1) in the gp41 viral envelope glycoprotein, thereby preventing conformational changes required for fusion of viral and cellular membranes and preventing the virus from entering a host cell.
    NCI
    U.S. National Cancer Institute, 2021
  • A synthetic 36-amino acid peptide that corresponds to the heptad repeat sequence of HIV-1 gp41. It blocks HIV cell fusion and viral entry and is used with other anti-retrovirals for combination therapy of HIV INFECTIONS and AIDS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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