Pharmacologic Substance
epipodophyllotoxin
[ eh-pih-poh-doh-fih-loh-tok-sin ]
Definitions related to epipodophyllotoxin:
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A substance being studied in the treatment of some types of cancer. Epipodophyllotoxin is extracted from the mandrake root Podophyllum peltatum. It is a type of topoisomerase inhibitor.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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(epipodophyllotoxin compound) An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death.NCI ThesaurusU.S. National Cancer Institute, 2021
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