Pharmacologic Substance
epipodophyllotoxin Audio
[ eh-pih-poh-doh-fih-loh-tok-sin ]
Definitions related to epipodophyllotoxin:
  • A substance being studied in the treatment of some types of cancer. Epipodophyllotoxin is extracted from the mandrake root Podophyllum peltatum. It is a type of topoisomerase inhibitor.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • (epipodophyllotoxin compound) An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death.
    NCI
    U.S. National Cancer Institute, 2021
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