Antibiotic
ertapenem
Brand Names:
Invanz
Effect:
Decreased Cell Wall Synthesis & Repair; Post Translation Protein Modification Alteration
May Treat:
Abdominal Abscess;
Bacteroides Infections;
Escherichia coli Infections;
Haemophilus Infections;
Intraabdominal Infections;
Klebsiella Infections;
Pelvic Infection;
Pneumonia;
Pyelonephritis;
Sepsis;
Soft Tissue Infections;
Staphylococcal Skin Infections;
Streptococcal Infections;
Urinary Tract Infections
More Information:
Definitions related to ertapenem:
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A 1-beta-methyl carbapenem and broad-spectrum beta-lactam antibiotic with bactericidal property. Ertapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, in particular PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition results in a weakening and subsequent lysis of the cell wall leading to cell death of Gram-positive and Gram-negative aerobic and anaerobic pathogens. This agent is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases.NCI ThesaurusU.S. National Cancer Institute, 2021
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A carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of Gram-positive and Gram-negative bacterial infections including intra-abdominal infections, acute gynecological infections, complicated urinary tract infections, skin infections, and respiratory tract infections. It is also used to prevent infection in colorectal surgery.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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