Pharmacologic Substance
etoposide Audio
[ ee-toh-poh-side ]
Brand Names:
Etopophos; Toposar
Effect:
Cellular Proliferation Alteration; Decreased DNA Integrity; Increased Cellular Death
May Treat:
Brain Neoplasms; Histiocytosis; Leukemia, Myeloid, Acute; Lung Neoplasms; Mycosis Fungoides; Neuroblastoma; Prostatic Neoplasms; Rhabdomyosarcoma; Sarcoma, Ewing; Sarcoma, Kaposi; Testicular Neoplasms; Trophoblastic Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to etoposide:
  • A drug used to treat testicular and small cell lung cancers. It is also being studied in the treatment of several other types of cancer. Vepesid blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of podophyllotoxin derivative and a type of topoisomerase inhibitor.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Glucopyranosyl substituted naphthalene derived from podophyllin; mutagen and immunosuppressant used in combination antineoplastic therapy for several human malignancies.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.