Pharmacologic Substance
teniposide Audio
[ teh-nih-poh-side ]
Effect:
Decreased DNA Integrity
May Treat:
Carcinoma, Small Cell; Leukemia, Lymphoid; Lung Neoplasms
Definitions related to teniposide:
  • A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An anticancer drug that is a podophyllotoxin derivative and belongs to the family of drugs called mitotic inhibitors.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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