Pharmacologic Substance
exatecan mesylate Audio
[ ek-suh-tee-kan meh-zih-layt ]
Definitions related to exatecan mesylate:
  • A semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An anticancer drug that is a type of topoisomerase inhibitor.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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