Pharmacologic Substance
exenatide
Brand Names:
Bydureon; Byetta
Effect:
Decreased Gastric Motility; Decreased Glucagon Secretion; Increased Insulin Secretion
May Treat:
Diabetes Mellitus, Type 2
More Information:
Definitions related to exenatide:
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A 39 amino acid peptide and synthetic version of exendin-4, a hormone found in the saliva of the venomous lizard Gila monster, with insulin secretagogue and antihyperglycemic activity. Exenatide is administered subcutaneously and mimics human glucagon-like peptide-1 (GLP-1). Compared to GLP-1, exenatide has a longer half-life of 2.4 hours.NCI ThesaurusU.S. National Cancer Institute, 2021
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A synthetic form of exendin-4, a 39-amino acid peptide isolated from the venom of the Gila monster lizard (Heloderma suspectum). Exenatide increases CYCLIC AMP levels in pancreatic acinar cells and acts as a GLUCAGON-LIKE PEPTIDE-1 RECEPTOR (GLP-1) agonist and incretin mimetic, enhancing insulin secretion in response to increased glucose levels; it also suppresses inappropriate glucagon secretion and slows gastric emptying. It is used an anti-diabetic and anti-obesity agent.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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