Pharmacologic Substance
fazarabine
[ fuh-zar-uh-been ]
Definitions related to fazarabine:
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5 azacytosine arabinoside; USP lists as an antineoplastic agent.CRISP ThesaurusNational Institutes of Health, 2006
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An anticancer drug that is a type of antimetabolite.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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