Pharmacologic Substance
flucytosine
[ floo-sahy-tuh-seen ]
Brand Names:
Ancobon
Effect:
RNA Integrity Alteration
May Treat:
AIDS-Related Opportunistic Infections;
Aspergillosis;
Candidiasis;
Chromoblastomycosis;
Meningitis, Cryptococcal
More Information:
Definitions related to flucytosine:
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A drug that treats infections caused by fungi.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A fluorinated cytosine analog that is used as an antifungal agent.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.NCI ThesaurusU.S. National Cancer Institute, 2021
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Fluorinated cytosine analog that is used as an antifungal agent.CRISP ThesaurusNational Institutes of Health, 2006
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