Pharmacologic Substance
fludarabine
Effect:
Decreased DNA Integrity
May Treat:
Leukemia, Lymphocytic, Chronic, B-Cell;
Lymphoma, Non-Hodgkin
More Information:
Definitions related to fludarabine:
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A fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Administered parenterally as a phosphate salt, fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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Nucleoside analog used alone or in combination with other agents to treat various cancers, especially leukemia.CRISP ThesaurusNational Institutes of Health, 2006
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The active ingredient in a drug used to treat B-cell chronic lymphocytic leukemia (CLL) that has not responded to treatment with other anticancer drugs or that has gotten worse. Fludarabine blocks cells from making DNA and may kill cancer cells. It is a type of purine antagonist and a type of ribonucleotide reductase inhibitor.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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