Pharmacologic Substance
fludarabine phosphate Audio
[ floo-dar-uh-been fos-fayt ]
Effect:
Decreased DNA Integrity
May Treat:
Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin
More Information:
ChemID; DailyMed; PDR
Definitions related to fludarabine phosphate:
  • A drug used to treat B-cell chronic lymphocytic leukemia (CLL) that has not responded to treatment with other anticancer drugs or that has gotten worse. It is also being studied in the treatment of other types of cancer. Fludara blocks cells from making DNA and may kill cancer cells. It is a type of purine antagonist and a type of ribonucleotide reductase inhibitor.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.
    NCI
    U.S. National Cancer Institute, 2021
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