Hormone
fludrocortisone
[ floo-droh-kor-tih-sone ]
Effect:
Decreased Distal Tubule Na+ Excretion; Decreased Mineralocorticoid Secretion; Increased Distal Tubule K+ Excretion
May Treat:
Addison Disease;
Adrenocortical Hyperfunction
More Information:
Definitions related to fludrocortisone:
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A synthetic corticosteroid with antiinflammatory and antiallergic properties. Fludrocortisone is a mineralocorticoid receptor and glucocorticoid receptor agonist that binds to cytoplasmic receptors, translocates to the nucleus and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic acid, a precursor to prostaglandins and leukotrienes, both important mediators in the pro-inflammatory response mechanism. In addition, this agent exerts its mineralocorticoid effect on the distal tubules and collecting ducts of the kidney by inducing permease, an enzyme that regulates Na+ permeability in cells, thereby enhancing Na+ reabsorption and water retention as well as increasing K+, H+ excretion.NCI ThesaurusU.S. National Cancer Institute, 2021
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A synthetic corticosteroid. It is used to replace steroid hormones normally produced by the adrenal gland.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A synthetic mineralocorticoid with anti-inflammatory activity.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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