Pharmacologic Substance
fluoroquinolone Audio
fluor·o·quin·o·lone [ floor-oh-kwih-noh-lone ]
Subclass of:
Quinolones
Definitions related to fluoroquinolones:
  • A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • (fluoroquinolone antibiotic) Any quinolone antibiotic with a fluorine (F) atom attached to the quinolone structure, with broad-spectrum antibacterial activity. Fluoroquinolones diffuse through the bacterial cell wall and act by inhibiting bacterial topoisomerase II, DNA gyrase and/or bacterial topoisomerase IV, which are enzymes involved in bacterial DNA replication. This prevents DNA replication and leads to a blockage of bacterial cell proliferation.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Fluoroquinolones exhibit concentration-dependent bactericidal activity by inhibiting the activity of DNA gyrase and topoisomerase, enzymes essential for bacterial DNA replication.
    Merck Manuals
    Merck & Co., Inc., 2020
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