Pharmacologic Substance
flutamide
[ floo-tuh-mide ]
Effect:
Testicular Endocrine Activity Alteration
May Treat:
Hirsutism;
Prostatic Neoplasms
More Information:
Definitions related to flutamide:
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A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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An antiandrogen with about the same potency as cyproterone in rodent and canine species.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An anticancer drug that is a type of antiandrogen.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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