Pharmacologic Substance
flutamide Audio
[ floo-tuh-mide ]
Effect:
Testicular Endocrine Activity Alteration
May Treat:
Hirsutism; Prostatic Neoplasms
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to flutamide:
  • A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • An antiandrogen with about the same potency as cyproterone in rodent and canine species.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An anticancer drug that is a type of antiandrogen.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.