Pharmacologic Substance
fluvastatin
Brand Names:
Lescol
Effect:
Decreased Cholesterol Synthesis
May Prevent:
Coronary Artery Disease
May Treat:
Coronary Artery Disease;
Hypercholesterolemia;
Hyperlipoproteinemias;
Hypertriglyceridemia
More Information:
Definitions related to fluvastatin:
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A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties.NCI ThesaurusU.S. National Cancer Institute, 2021
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An indole-heptanoic acid derivative that inhibits HMG COA REDUCTASE and is used to treat HYPERCHOLESTEROLEMIA. In contrast to other statins, it does not appear to interact with other drugs that inhibit CYP3A4.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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