Pharmacologic Substance
fosaprepitant dimeglumine
[ fos-uh-preh-pih-tunt dy-meg-loo-meen ]
Effect:
Emesis Suppression
May Prevent:
Nausea; Vomiting
More Information:
Definitions related to fosaprepitant dimeglumine:
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A drug used together with other drugs to prevent and control nausea and vomiting caused by cancer treatment. It is given in a vein. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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The dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis.NCI ThesaurusU.S. National Cancer Institute, 2021
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