Pharmacologic Substance
foscarnet
Brand Names:
Foscavir
Effect:
Decreased DNA Replication; Decreased Protein Synthesis
May Treat:
Cytomegalovirus Infections; Herpes Genitalis
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to foscarnet:
  • A synthetic organic analog of inorganic pyrophosphate with activity against several types of viruses, but primarily used for the treatment of cytomegalovirus retinitis. Foscarnet selectively blocks the pyrophosphate binding site of virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases. Because this agent crosses the blood brain barrier, it may be used in the treatment of viral infections of the central nervous system.
    NCI
    U.S. National Cancer Institute, 2021
  • An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Phosphonoformate (trisodium); anticytomegaloviral agent with potential for treating AIDS retinopathy.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.