Antibiotic
fosfomycin
Brand Names:
Monurol
Effect:
Decreased Cell Wall Synthesis & Repair
May Treat:
Escherichia coli Infections; Gram-Positive Bacterial Infections; Klebsiella Infections; Proteus Infections; Serratia Infections; Urinary Tract Infections
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to fosfomycin:
  • A phosphoenolpyruvate analogue and a synthetic broad-spectrum antibiotic with antimicrobial and bactericidal properties. Fosfomycin binds to and inactivates the enzyme enolpyruvate transferase. This leads to an irreversible blockage of the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the first steps of bacterial cell wall synthesis, thereby eventually causing cell lysis and bacterial cell death.
    NCI
    U.S. National Cancer Institute, 2021
  • An antibiotic produced by Streptomyces fradiae.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Fosfomycin is a novel class of antibacterial drugs with a chemical structure unrelated to other known antibiotics. It is a bactericidal drug that disrupts cell wall synthesis by inhibiting phosphoenolpyruvate synthetase and thus interferes with the production of peptidoglycan.
    Merck Manuals
    Merck & Co., Inc., 2025
Try this search on: Farlex, Merriam-Webster, Oxford Dictionary, or Wordnik

This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.