Antibiotic
fosfomycin
Brand Names:
Monurol
Effect:
Decreased Cell Wall Synthesis & Repair
May Treat:
Escherichia coli Infections;
Gram-Positive Bacterial Infections;
Klebsiella Infections;
Proteus Infections;
Serratia Infections;
Urinary Tract Infections
More Information:
Definitions related to fosfomycin:
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A phosphoenolpyruvate analogue and a synthetic broad-spectrum antibiotic with antimicrobial and bactericidal properties. Fosfomycin binds to and inactivates the enzyme enolpyruvate transferase. This leads to an irreversible blockage of the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the first steps of bacterial cell wall synthesis, thereby eventually causing cell lysis and bacterial cell death.NCI ThesaurusU.S. National Cancer Institute, 2021
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An antibiotic produced by Streptomyces fradiae.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Fosfomycin is a novel class of antibacterial drugs with a chemical structure unrelated to other known antibiotics. It is a bactericidal drug that disrupts cell wall synthesis by inhibiting phosphoenolpyruvate synthetase and thus interferes with the production of peptidoglycan.Merck & Co., Inc., 2020
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