Pharmacologic Substance
gemcitabine hydrochloride
[ jem-sy-tuh-been hy-droh-klor-ide ]
Effect:
Decreased DNA Integrity; Increased Cellular Death
May Treat:
Breast Neoplasms;
Carcinoma, Non-Small-Cell Lung;
Carcinoma, Pancreatic Ductal;
Ovarian Neoplasms
More Information:
Definitions related to gemcitabine hydrochloride:
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A drug used to treat pancreatic cancer that is advanced or has spread. It is also used with other drugs to treat breast cancer that has spread, advanced ovarian cancer, and non-small cell lung cancer that is advanced or has spread. It is also being studied in the treatment of other types of cancer. Gemcitabine hydrochloride blocks the cell from making DNA and may kill cancer cells.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.NCI ThesaurusU.S. National Cancer Institute, 2021
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