Antibiotic
gemifloxacin
Brand Names:
Factive
Effect:
Decreased DNA Integrity; Decreased DNA Replication; Decreased Transcription to RNA
May Treat:
Bronchitis;
Community-Acquired Infections;
Gram-Negative Bacterial Infections;
Pneumonia, Pneumococcal;
Urinary Tract Infections
More Information:
Definitions related to gemifloxacin:
-
A fluoroquinolone antibiotic with antimicrobial property. Gemifloxacin enters bacterial cells by diffusion through integral membrane porin pathway before targeting both DNA gyrase and topoisomerase IV, two enzymes critical for DNA replication and repair. This agent binds to the DNA/DNA-gyrase complex and inhibits the A subunits of the enzyme thereby preventing the bacterial chromosome from rejoining. This interferes with DNA replication and repair processes as well as transcription, and ultimately leads to bacterial cell death. Gemifloxacin targets at both Gram-positive, -negative and atypical human pathogens.NCI ThesaurusU.S. National Cancer Institute, 2021
-
A naphthyridine and fluoroquinolone derivative antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used for the treatment of community-acquired pneumonia and acute bacterial infections associated with chronic bronchitis.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
Return to OpenMD Medical Dictionary
> G
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.