Genetic Function
gene rearrangement
[ jeen ree-uh-reynj-muh nt ]
Definitions related to gene rearrangement:
  • Any DNA sequence rearrangement that results in the creation of a novel protein-coding capacity. Within certain genes, gene rearrangement is a normal part of development, facilitating the affinity maturation of B and T lymphocytes as well as class switching of immunoglobulins.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Covalent DNA changes in cells during normal differentiation resulting in new sequences, expression, or gene products; mechanism of binding site diversification for antibodies, certain receptors, and possibly other proteins.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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