Therapeutic or Preventive Procedure
gene therapy
gene ther·a·py [ jeen thayr-uh-pee ]
Definitions related to gene therapy:
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Application of genetic material (usually DNA) into cells in order to permanently correct an inherited disease or acquired disease.NCI ThesaurusU.S. National Cancer Institute, 2021
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Correction of a genetic defect by replacing an abnormal gene with a normal gene.Harvard Dictionary of Health TermsHarvard Medical Publishing, 2011
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Introduction of functioning gene or genes into cells for the purpose of correcting an inborn genetic error, treating a disease by restoring or adding gene expression, or providing a new function to the cell; new genes may be introduced into proliferating cells in vivo (e.g., bone marrow) or in vitro (e.g., fibroblast cultures) and the modified cells transferred to the site where the gene expression is required.CRISP ThesaurusNational Institutes of Health, 2006
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The processes by which highly specific gene sequences in a host cell are targeted and regulated for the purpose of reversing and or curing a disease.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Therapy based on ex vivo or in vivo gene modification of cells using specific technologies, e.g., viral vectors and direct genome editing technologies. NOTE: A particular example of this is the therapy with gene-modified T cells (chimeric antigen receptor (CAR) T-cell therapies) used as immunotherapy in oncology.CDISC TerminologyClinical Data Interchange Standards Consortium (CDISC), 2021
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Treatment that alters a gene. In studies of gene therapy for cancer, researchers are trying to improve the body's natural ability to fight the disease or to make the cancer cells more sensitive to other kinds of therapy.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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Although gene therapy is defined as any treatment that changes gene function, it is often thought of as the insertion of normal genes into the cells of a person who lacks such normal genes because of a specific genetic disorder. This technique is called gene insertion therapy or insertion gene therapy. The normal genes can be...Merck & Co., Inc., 2020
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Gene therapy involves altering the genes inside your body's cells in an effort to treat or stop disease.Mayo Foundation for Medical Education and Research
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Gene therapy, introduction of a normal gene into an individual's genome in order to repair a mutation that causes a genetic disease. When a normal gene is inserted into the nucleus of a mutant cell, the gene most likely will integrate into a chromosomal site different from the defective allele...Encyclopedia Britannica, Inc., 2020
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