Biologically Active Substance
genistein Audio
[ jeh-nis-teen ]
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to genistein:
  • A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An antioxidant chemical found in certain plants, like soybeans.
    Harvard Dictionary of Health Terms
    Harvard Medical Publishing, 2011
  • An isoflavone found in soy products. Soy isoflavones are being studied to see if they help prevent cancer.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An isoflavone with a hydroxyl group on the B-ring and a second hydroxyl group on the A-ring.
    CRCH Nutrition Terminology
    Cancer Research Center of Hawaii, University of Hawaii, 2021
  • An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Trihydroxyisoflavone; phytoestrogen found in soy based foods; may have cancer chemoprotective activity.
    CRISP Thesaurus
    National Institutes of Health, 2006
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